A potent

IKK2 Inhibitor VI – 5 mg

Brand:
Cayman
CAS:
354811-10-2
Storage:
-20
UN-No:
Non-Hazardous - /

Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM).{17345} It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.{28299,28300}  

 

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Description

A potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM); used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses,

Formal name: 2-[(aminocarbonyl)amino]-5-phenyl-3-thiophenecarboxamide

Synonyms:  5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide

Molecular weight: 261.3

CAS: 354811-10-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|IKKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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