Antigen: His-tagged full length human IKKγ • Host: Mouse • Clone: 72C627 • Isotype: IgG1 • Species Reactivity: (+) Human

IKKγ Monoclonal Antibody (Clone 72C627) – 1 ea

Brand:
Cayman
Storage:

Nuclear Factor-κB (NF-κB) is sequestered in the cytoplasm by the IκB family of inhibitory proteins that mask the nuclear localization signal of NF-κB, thereby preventing translocation of NF-κB to the nucleus.{18540} External stimuli such as tumor necrosis factor or other cytokines result in phosphorylation and degradation of IκB, releasing NF-κB dimers. NF-κB dimers subsequently translocate to the nucleus and activate target genes. Synthesis of IκBα is autoregulated.{18541} IκB proteins are phosphorylated by IκB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and IKK3/γ.{18542,18543,18544,18658,18545} IKKγ preferentially interacts with IKKβ and is required for activation of IKK complex. IKKγ is also known as NF-κB essential modulator (NEMO).{18545} The human T cell leukemia virus type I Tax oncoprotein that activates NF-κB binds neither to IKKα nor IKKβ, but complexes directly with IKKγ.{18659} This suggests that IKKγ may be a key molecule acting as an adapter for oncoprotein specific signaling to IKKα and IKKβ.{18659}  

 

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SKU: 13931 - 1 ea Category:

Description

Antigen: His-tagged full length human IKKγ • Host: Mouse • Clone: 72C627 • Isotype: IgG1 • Species Reactivity: (+) Human, mouse • Application(s): WB • IκB proteins are phosphorylated by IκB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and IKK3/γ. IKKγ preferentially interacts with IKKβ and is required for activation of the IKK complex.

Synonyms: IKK3|NEMO|NF-κB Essential Modulator

Immunogen: His-tagged full length human IKKγ

Formulation: 100 µg of protein G-purified IgG

Isotype: IgG1

Applications: WB

Origin:

Stability: 180 days

Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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