Description
Immunoglobulin D (IgD) is a member of the immunoglobulin superfamily of glycoproteins that functions as a B cell antigen receptor (BCR) and has roles in adaptive immunity.{52717} Human IgD is composed of two Igδ heavy chains of approximately 50 kDa each and two Igĸ or Igλ light chains of approximately 25 kDa each.{52718,28520} It is expressed on the surface of antigen-naïve mature B cells, which are found in germinal centers and peripheral blood, as well as certain subsets of circulating memory B cells.{52717,52719} IgD levels increase during B cell maturation and are regulated by alternative splicing of an mRNA transcript that is common to the µ and δ heavy chains of IgM and IgD, respectively.{52717,52720} Upon antigen activation, IgD can undergo class switch recombination to the immunoglobulin isotypes IgA, IgE, or IgG, each of which has a distinct effector function.{52721} IgD can also be produced from IgM by class switch recombination, leading to the generation of IgD-secreting plasma cells that have roles in mucosal immunity.{52722} IgD binds to basophil and mast cell lines, as well as the respiratory pathogens M. catarrhalis and H. influenzae, in vitro.{52723} Serum IgD levels are increased in patients with a variety of conditions, including leprosy, tuberculosis, malaria, or Hodgkin’s lymphoma and is a hallmark of hyperimmunoglobulinemia D syndrome (HIDS), an autoinflammatory condition characterized by febrile episodes.{52724} Cayman’s IgD (human) Rabbit Monoclonal Antibody can be used for ELISA.
Synonyms: Immunoglobulin D
Immunogen: Human IgD
Formulation: 100 µg of protein A-purified monoclonal antibody
Isotype: IgG
Applications: ELISA
Origin:
Stability: 365 days
Application|ELISA||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer||Research Area|Cardiovascular System|Blood|Serum Proteins||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases|Leprosy||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis||Research Area|Infectious Disease|Parasitic Diseases|Malaria
