Description
Immunoglobulins are members of the glycoprotein superfamily that play a central role in the adaptive immune response.{28520} They are produced by B cells and later secreted by plasma cells as antibodies.{55225} Immunoglobulins are composed of two heavy chains of approximately 50 kDa each and two light chains of approximately 25 kDa each.{28520} The heavy chains are linked together by disulfide bonds to form an Fc region and also combine with the light chains to form the Fab region, which mediate receptor and antigen binding, respectively.{55171} Mammalian immunoglobulins contain either Igκ or Igλ light chains, each of which are composed of a constant and variable domain.{28687} The ratio of Igκ to Igλ light-chain containing antibodies varies between species, with ratios of 20:1, 2:1, and 1:20 in mice, humans, and cattle, respectively. Igκ and Igλ free light chains (FLCs) are produced during immunoglobulin synthesis, and accumulation of these FLCs is associated with various disorders, including light-chain deposition disease, multiple myeloma, rheumatoid arthritis, diabetic nephropathy, and systemic lupus erythematosus (SLE).{55225,55232,53885} Cayman’s Ig Light Chain (human) Rabbit Monoclonal Antibody be used for ELISA, flow cytometry (FC), immunocytochemistry (ICC), and immunohistochemistry (IHC) applications. The antibody recognizes both the Igĸ and Igλ light chains from human samples.
Synonyms: Immunoglobulin light chain
Immunogen: Human IgG
Formulation: 100 µg of protein A-purified monoclonal antibody
Isotype: IgG
Applications: ELISA, ICC, IHC
Origin:
Stability: 365 days
Application|ELISA||Application|Flow Cytometry||Application|Immunocytochemistry||Application|Immunohistochemistry||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer||Research Area|Cardiovascular System|Blood|Serum Proteins||Research Area|Cardiovascular System|Kidney & Renal Disease|Diabetic Nephropathy||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity|Lupus||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis
