A nitrogen mustard alkylating agent used as a chemotherapeutic agent against advanced transitional cell carcinoma; serves as a prodrug that is metabolized to its active DNA alkylating form

Ifosfamide – 250 mg

Brand:
Cayman
CAS:
3778-73-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Ifosfamide is a nitrogen mustard alkylating agent used as a chemotherapeutic agent against advanced transitional cell carcinoma.{21579} It is a structural derivative of cyclophosphamide (Item No. 13849) that was developed for improved solubility and antitumor activity. Like cyclophosphamide, ifosfamide serves as a prodrug that is either metabolized to its active DNA alkylating form, isophosphoramide mustard, or catabolized through a dechloroethylation pathway to the neurotoxic and nephrotoxic chloroacetaldehyde.{28725}  

 

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Description

A nitrogen mustard alkylating agent used as a chemotherapeutic agent against advanced transitional cell carcinoma; serves as a prodrug that is metabolized to its active DNA alkylating form, isophosphoramide mustard

Formal name: N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

Synonyms:  Isophosphamide|NSC 109724

Molecular weight: 261.1

CAS: 3778-73-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|DNA Alkylating Agents||Research Area|Cancer|DNA Damage and Repair|DNA Alkylating Agents

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