An inhibitor of the IFN-α-IFNAR protein-protein interaction (Kd = 4 µM for binding to IFN-α); inhibits virus-induced increases in the production of IFN-α and IL-12 in BM-pDCs infected with MVA or VSV at 18 µM; reduces increases in IL-12 production induced by stimulation with CpG 2216 or poly(I:C) in the same cells

IFN-α-IFNAR-IN-1 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
2070014-98-9
Storage:
-20
UN-No:
Non-Hazardous - /

IFN-α-IFNAR-IN-1 is an inhibitor of the protein-protein interaction between the cytokine IFN-α and the IFN-α/β receptor (IFNAR; Kd = 4 µM for binding to IFN-α).{60002} It inhibits virus-induced increases in the production of IFN-α and IL-12 in bone marrow-derived plasmacytoid dendritic cells (BM-pDCs) infected with modified Vaccinia virus Ankara (MVA) or vesicular stomatitis virus (VSV) when used at a concentration of 18 µM. IFN-α-IFNAR-IN-1 also reduces increases in IL-12 production induced by stimulation with the toll-like receptor 9 (TLR9) agonist CpG 2216 or the TLR3 agonist poly(I:C) in the same cells.  

 

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SKU: 30960 - 10 mg Category:

Description

An inhibitor of the IFN-α-IFNAR protein-protein interaction (Kd = 4 µM for binding to IFN-α); inhibits virus-induced increases in the production of IFN-α and IL-12 in BM-pDCs infected with MVA or VSV at 18 µM; reduces increases in IL-12 production induced by stimulation with CpG 2216 or poly(I:C) in the same cells

Formal name: N-methyl-2-(1-naphthalenylthio)-benzenemethanamine, monohydrochloride

Synonyms: 

Molecular weight: 315.9

CAS: 2070014-98-9

Purity: ≥98%

Formulation: A crystalline solid

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