A phenol with anticancer activity; reduces the viability of R182S

Idronoxil – 5 mg

Brand:
Cayman
CAS:
81267-65-4
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Idronoxil is a phenol and derivative of genistein (Item No. 10005167) that has been found in B. tournefortii and has anticancer activity.{52686,52684,52685} It reduces the viability of R182S, R127, Hey, CP70, A2780, R187, R188, and R207 primary ovarian cancer cells, but not non-cancerous ovarian surface epithelial (OSE) cells, when used at a concentration of 10 µg/ml.{52684} Idronoxil (1 µg/ml) reduces colony formation and induces apoptosis in R127 and CP70 primary ovarian cancer cells, respectively, and restores sensitivity to Fas-mediated apoptosis in CP70 cells. In vivo, idronoxil (50 and 75 mg/kg) increases latency to tumor formation and reduces tumor multiplicity in a rat model of mammary carcinogenesis induced by dimethylbenz[a]anthracene (DMBA).{52685}  

 

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SKU: 30783 - 5 mg Category:

Description

A phenol with anticancer activity; reduces the viability of R182S, R127, Hey, CP70, A2780, R187, R188, and R207 primary ovarian cancer cells at 10 µg/ml; reduces colony formation and induces apoptosis in R127 and CP70 primary ovarian cancer cells, respectively, and restores sensitivity to Fas-mediated apoptosis in CP70 cells at 1 µg/ml; increases latency to tumor formation and reduces tumor multiplicity in a rat model of DMBA-induced mammary carcinogenesis

Formal name: 3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol

Synonyms:  Haginin E|Phenoxodiol

Molecular weight: 240.3

CAS: 81267-65-4

Purity: ≥98%

Formulation: A solid

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