A small molecule inducer of definitive endoderm from embryonic stem cells; induces the differentiation of Sox17+/FoxA2+-expressing pancreatic progenitors from human and mouse embryonic stems cells (EC50 = 223 nM in vitro) by activating the TGF-β signaling pathway

IDE2 – 10 mg

Brand:
Cayman
CAS:
1136466-93-7
Storage:
-20
UN-No:
Non-Hazardous - /

IDE2 is a small molecule capable of inducing definitive endoderm from embryonic stem cells. It has been shown to induce the differentiation of Sox17+/FoxA2+-expressing pancreatic progenitors from human and mouse embryonic stems cells (EC50 = 223 nM in vitro) by activating the TGF-β signaling pathway.{17965} IDE2-derived endodermal cells injected into E8.75 mouse embryos ex vivo have been shown to incorporate into the developing gut tube, contributing to its formation.{17965} Furthermore, when treated with either indolactam V (Item No. 14647) or a standard regimen of the growth factor FGF-10, retinoic acid, and hedgehog inhibitors, IDE2-induced endodermal cells can form Pdx1-expressing pancreatic progenitors.{17965}  

 

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Description

A small molecule inducer of definitive endoderm from embryonic stem cells; induces the differentiation of Sox17+/FoxA2+-expressing pancreatic progenitors from human and mouse embryonic stems cells (EC50 = 223 nM in vitro) by activating the TGF-β signaling pathway

Formal name: 1-(2-cyclopentylidenehydrazide)-heptanedioic acid

Synonyms: 

Molecular weight: 240.3

CAS: 1136466-93-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Stem Cell Research|Differentiation

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