An inhibitor of human recombinant PDE5 (IC50 = 5.9 µM); used to treat erectile dysfunction and has been shown to have anti-cancer and antioxidant activity; induces differentiation of cardiomyocytes and increases the proliferation and differentiation of cultured human osteoblasts

Icariin – 5 g

Brand:
Cayman
CAS:
489-32-7
Storage:
-20
UN-No:
Non-Hazardous - /

The cyclic nucleotide second messenger guanosine 3’5’-cyclic monophosphate (cGMP) is an important mediator of signal transduction and hence a wide range of cellular processes. It is generated by soluble- and particulate-type guanylyl cyclase and degraded via members of the phosphodiesterase (PDE) protein family. Icariin, the active component of the Chinese medicinal plant E. brevicornum, is an inhibitor of human recombinant PDE5 with an IC50 value of 5.9 µM.{17617} It is a prenylated flavonol that has been used to treat erectile dysfunction and has been shown to have anti-cancer and antioxidant activity.{17873} At a concentration of 1 x 107 mol/L, icariin induces differentiation of cardiomyocytes and upregulates the expression of cardiac genes.{17874} At 20 µg/ml, icariin increases the proliferation and differentiation of cultured human osteoblasts, which appears to be mediated in part by upregulating bone morphogenetic protein 2 mRNA.{17875}  

 

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Description

An inhibitor of human recombinant PDE5 (IC50 = 5.9 µM); used to treat erectile dysfunction and has been shown to have anti-cancer and antioxidant activity; induces differentiation of cardiomyocytes and increases the proliferation and differentiation of cultured human osteoblasts

Formal name: 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 676.6

CAS: 489-32-7

Purity: ≥97%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cancer||Research Area|Cardiovascular System|Heart|Cardiogenesis||Research Area|Cell Biology|Cell Signaling|cGMP Signaling

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