A Kv7 channel activator; selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM

ICA 069673 – 5 mg

Brand:
Cayman
CAS:
582323-16-8
Storage:
-20
UN-No:
Non-Hazardous - /

ICA 069673 is a heteromeric Kv7 channel activator.{39323,39324} It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner.{39324} ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM).{39323} Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively).{39323} Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy.  

 

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SKU: 22995 - 5 mg Category:

Description

A Kv7 channel activator; selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner; has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM); increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively),

Formal name: N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-benzamide

Synonyms: 

Molecular weight: 269.6

CAS: 582323-16-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience|Seizure Disorders

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