A cell-permeable selective inhibitor of the PI3K catalytic subunit p110δ (IC50 = 0.5 μM). It less effectively inhibits p110γ and p110β (IC50 = 29 and 75 μM

IC-87114 – 1 mg

Brand:
Cayman
CAS:
371242-69-2
Storage:
-20
UN-No:
Non-Hazardous - /

The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival.{13740,17822} IC-87114 is a cell-permeable selective inhibitor of the PI3K catalytic subunit p110δ (IC50 = 0.5 μM).{24748} It less effectively inhibits p110γ and p110β (IC50 = 29 and 75 μM, respectively) and has no significant effect on p110α and several other kinases.{24748,24749} This product is used to elucidate the role of p110δ in cells, including neutrophils, natural killer cells, and other types of leukocytes.{24748,24749,24750,21846,24751} It has also been used in mice.{24752}  

 

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SKU: 11589 - 1 mg Category:

Description

A cell-permeable selective inhibitor of the PI3K catalytic subunit p110δ (IC50 = 0.5 μM). It less effectively inhibits p110γ and p110β (IC50 = 29 and 75 μM, respectively) and has no significant effect on p110α and several other kinases

Formal name: 2-[(6-amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone

Synonyms: 

Molecular weight: 397.4

CAS: 371242-69-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling

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