An orally bioavailable inhibitor of mitochondrial complex I; inhibits the ubiquinone reduction activity of isolated murine mitochondrial complex I at 60 nM; reduces basal and spare respiratory capacities and increases glycolytic flux in primary CLL cells at 100 nM; induces apoptosis in CLL cells grown under low glucose conditions or when administered in combination with 2-deoxy-D-glucose; induces tumor regression in a glycolysis-deficient NB1 mouse xenograft model when administered at doses of 5 and 10 mg/kg

IACS-010759 – 1 mg

Brand:
Cayman
CAS:
1570496-34-2
Storage:
-20
UN-No:
Non-Hazardous - /

IACS-010759 is an orally bioavailable inhibitor of complex I of the mitochondrial electron transport chain.{42644,42645} It inhibits the ubiquinone reduction activity of isolated murine mitochondrial complex I when used at a concentration of 60 nM.{42644} IACS-010759 (100 nM) reduces basal and spare respiratory capacities and increases glycolytic flux in primary chronic lymphocytic leukemia (CLL) cells.{42645} It also induces apoptosis in CLL cells grown under low glucose conditions or when administered in combination with 2-deoxy-D-glucose (Item No. 14325). IACS-010759 (5 and 10 mg/ml) induces tumor regression in a glycolysis-deficient NB1 mouse xenograft model.{42644}  

 

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SKU: 25867 - 1 mg Category:

Description

An orally bioavailable inhibitor of mitochondrial complex I; inhibits the ubiquinone reduction activity of isolated murine mitochondrial complex I at 60 nM; reduces basal and spare respiratory capacities and increases glycolytic flux in primary CLL cells at 100 nM; induces apoptosis in CLL cells grown under low glucose conditions or when administered in combination with 2-deoxy-D-glucose; induces tumor regression in a glycolysis-deficient NB1 mouse xenograft model when administered at doses of 5 and 10 mg/kg

Formal name: 4-(methylsulfonyl)-1-[3-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-1,2,4-triazol-1-yl]methyl]phenyl]-piperidine

Synonyms: 

Molecular weight: 562.6

CAS: 1570496-34-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Metabolism||Research Area|Cell Biology|Mitochondrial Biology

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