A high-affinity TP receptor antagonist; produces platelet shape change

I-SAP – 1 mg

Brand:
Cayman
CAS:
133538-58-6
Storage:
-20
UN-No:
De Minimis - 1170 / 3

I-SAP is a high affinity TP receptor antagonist. At physiologic pH, I-SAP produces platelet shape change, but not aggregation, with an EC50 value of 9.7 nM. I-SAP binds to human platelets with the maximum binding obtained between pH 6.5 and pH 7.4. In washed human platelets, the Kd for I-SAP is 468 pM at pH 7.4 and 490 pM at pH 6.5.{858}  

 

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Description

A high-affinity TP receptor antagonist; produces platelet shape change, but not aggregation, with an EC50 value of 9.7 nM

Formal name: (Z)-[3S-[1α,2α,3β,5α]]-7-[3-[[(4-iodophenyl)sulfonyl]amino]-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-5-heptenoic acid

Synonyms:  Iodophenyl sulfonyl amino pinane Thromboxane A2|Iodophenyl sulfonyl amino pinane TXA2

Molecular weight: 531.4

CAS: 133538-58-6

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Thromboxanes||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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