A selective inhibitor of CBP and EP300 which directly binds their bromodomains (Kds = 0.142 and 0.625 μM); shows only weak cross reactivity with the bromodomains of BET proteins and shows no interaction with other bromodomains

I-CBP112 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
2147701-33-3
Storage:
-20
UN-No:
Non-Hazardous - /

cAMP-responsive element-binding protein binding protein (CREBBP) and E1A-associated protein p300 (EP300) are transcriptional co-activators that modulate DNA replication, DNA repair, cell growth, transformation, and development.{22609,22611} Both CBP and EP300 contain bromodomains, which mediate their binding to acetylated lysine residues on histones and other proteins.{21581} I-CBP112 is a selective inhibitor of CBP and EP300 that directly binds their bromodomains (Kds = 0.142 and 0.625 μM, respectively). Developed by the Structural Genomics Consortium (SGC), this compound shows only weak cross-reactivity with the bromodomains of bromodomain and extra-terminal proteins and shows no interaction with other bromodomains.  

 

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Description

A selective inhibitor of CBP and EP300 which directly binds their bromodomains (Kds = 0.142 and 0.625 μM); shows only weak cross reactivity with the bromodomains of BET proteins and shows no interaction with other bromodomains

Formal name: 1-[7-(3,4-dimethoxyphenyl)-2,3-dihydro-9-[[(3S)-1-methyl-3-piperidinyl]methoxy]-1,4-benzoxazepin-4(5H)-yl]-1-propanone, monohydrochloride

Synonyms: 

Molecular weight: 505.1

CAS: 2147701-33-3

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Chromatin Reader Interactions||Research Area|Epigenetics, Transcription, & Translation|Readers|Bromodomains

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