A selective BRD9 bromodomain inhibitor (pIC50 = 7.3; pKd = 8.7); used to identify genes regulated by BRD9 in Kasumi-1 cells involved in cancer and immune response signaling

I-BRD9 – 5 mg

Brand:
Cayman
CAS:
1714146-59-4
Storage:
-20
UN-No:
Non-Hazardous - /

BRD9 contains a single bromodomain and has five isoforms that are produced by alternative splicing.{20313} It is thought to function in chromatin remodeling as part of the SWI/SNF complex. I-BRD9 is a BRD9 bromodomain inhibitor with a pIC50 value of 7.3 and a pKd value of 8.7.{28931} It displays 700-fold greater selectivity over the tandem bromodomain-containing BET family of proteins and 200-fold selectivity over the highly homologous BRD7 bromodomain.{28931} This compound has been used to identify genes regulated by BRD9 in Kasumi-1 cells involved in cancer and immune response signaling.{28931} See the Structural Genomics Consortium (SGC) website for more information.  

 

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Description

A selective BRD9 bromodomain inhibitor (pIC50 = 7.3; pKd = 8.7); used to identify genes regulated by BRD9 in Kasumi-1 cells involved in cancer and immune response signaling

Formal name: 5-ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]-thieno[3,2-c]pyridine-2-carboximidamide

Synonyms: 

Molecular weight: 497.6

CAS: 1714146-59-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Chromatin Reader Interactions||Research Area|Epigenetics, Transcription, & Translation|Readers|Bromodomains

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