Description
IκBζ is an ankyrin repeat-containing nuclear protein that is highly homologous to the IκB family member Bcl-3. Transcription of IκBζ is upregulated by stimulation with TLR ligands, IL-1, and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkBz preferentially associates with the NF-κB subunit p50 rather than p65 and recombinant IκBζ proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.
Synonyms: INAP|MAIL
Immunogen: synthetic peptide corresponding to mouse IkBζ amino acids 684-699 and 285-298
Formulation: 100 µg of protein G-purified IgG in 200 µl PBS, containing 0.2% gelatin and 0.05% sodium azide.
Isotype:
Applications: WB
Origin: Animal/Rabbit
Stability: 365 days
Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity
