A potent

HZ52 – 10 mg

Brand:
Cayman
CAS:
1077626-51-7
Storage:
-20
UN-No:
Non-Hazardous - /

HZ-52 is a potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes.{19457} HZ-52 also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects against platelet-activating factor-induced shock in mice when given intraperitoneally (10 mg/kg).{19457}  

 

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SKU: 10888 - 10 mg Category:

Description

A potent, reversible 5-LO inhibitor, blocking LTB4 synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes; also attenuates LTB4 synthesis, prevents carrageenan-induced pleurisy, and protects against PAF-induced shock in mice when given intraperitoneally

Formal name: 2-(4-(bipheny-4-ylamino)-6-chloropyrimidiny-2-ylthio)-octanoic acid

Synonyms: 

Molecular weight: 456

CAS: 1077626-51-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock

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