An NS3/4A protease and dengue virus inhibitor; inhibits NS3/4A protease (IC50 = 1 µM); inhibits infectious HCV virus replication (IC50 = 0.82 µM); inhibits dengue virus serotype 2 replicon activity (EC50 = 2.8 nM) without exhibiting toxicity (CC50 = >10 µM)

HZ-1157 – 5 mg

Brand:
Cayman
CAS:
1009734-33-1
Storage:
-20
UN-No:
Non-Hazardous - /

HZ-1157 is an inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (IC50 = 1 µM in an NS3/4A secreted embryonic alkaline phosphatase assay).{37188} It inhibits infectious HCV virus replication in Huh7.51 cells (IC50 = 0.82 µM). It also inhibits dengue virus serotype 2 replicon activity (EC50 = 2.8 nM in BHK-D2RepT cells with high NS3 levels) without exhibiting cytotoxicity (CC50 = >10 µM).{37187}  

 

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SKU: 23436 - 5 mg Category:

Description

An NS3/4A protease and dengue virus inhibitor; inhibits NS3/4A protease (IC50 = 1 µM); inhibits infectious HCV virus replication (IC50 = 0.82 µM); inhibits dengue virus serotype 2 replicon activity (EC50 = 2.8 nM) without exhibiting toxicity (CC50 = >10 µM)

Formal name: 5-(1,1-dimethylethoxy)-2,4-quinazolinediamine

Synonyms: 

Molecular weight: 232.3

CAS: 1009734-33-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Protease Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Dengue||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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