A fungal metabolite; decreases the viability of

Hypocrellin B – 1 mg

Brand:
Cayman
CAS:
123940-54-5
Storage:
-20
UN-No:
Non-Hazardous - /

Hypocrellin B is a fungal metabolite that has been found in H. bambuase and has anticancer and antibacterial activities.{45497,45498} It acts as a sonosensitizer, decreasing the viability of MDA-MB-231 breast cancer cells and inducing apoptosis in the presence of ultrasound exposure, effects that can be inhibited by the caspase inhibitor z-VAD-FMK.{45497} It also increases the production of reactive oxygen species (ROS) in MDA-MB-231 cells when used at a concentration of 2.5 µM with concomitant ultrasound exposure. Hypocrellin B (20 µM), in combination with ultrasound sonication, is active against methicillin-resistant S. aureus (MRSA).{45498}  

 

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SKU: 28544 - 1 mg Category:

Description

A fungal metabolite; decreases the viability of, and induces apoptosis in, MDA-MB-231 breast cancer cells when used in the presence of ultrasound exposure; increases the production of ROS in MDA-MB-231 cells at 2.5 µM with concomitant ultrasound exposure; active against MRSA at 20 µM in combination with ultrasound sonication

Formal name: 3-acetyl-6,11-dihydroxy-4,8,9,13-tetramethoxy-2-methyl-1H-cyclohepta[ghi]perylene-5,12-dione

Synonyms: 

Molecular weight: 528.5

CAS: 123940-54-5

Purity: ≥98%

Formulation: A crystalline solid

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