A perylenequinoid with diverse biological activities; active against C. albicans

Hypocrellin A – 25 mg

Brand:
Cayman
CAS:
77029-83-5
Storage:
-20
UN-No:
Non-Hazardous - /

Hypocrellin A is a perylenequinoid that has been found in Shiraia bambusicola and has diverse biological activities.{52379,52380} It is active against C. albicans, C. parapsilosis, and C. tropicalis fungi (IC50s = 0.65, 1, and 85 µg/ml, respectively), as well as S. aureus, methicillin-resistant S. aureus (MRSA), P. aeruginosa, and M. intracellulare bacteria (IC50s = 3, 7, 10, and 2.5 µg/ml, respectively).{52379} Hypocrellin A is also active against L. donovani promastigotes (IC50 = 0.27 µg/ml). Upon photoactivation with UV radiation, hypocrellin A induces production of reactive oxygen species and apoptosis and reduces cell viability of A549 cancer cells.{52380}  

 

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SKU: 29933 - 25 mg Category:

Description

A perylenequinoid with diverse biological activities; active against C. albicans, C. parapsilosis, and C. tropicalis fungi (IC50s = 0.65, 1, and 85 µg/ml, respectively), as well as S. aureus, MRSA, P. aeruginosa, and M. intracellulare bacteria (IC50s = 3, 7, 10, and 2.5 µg/ml, respectively); active against L. donovani promastigotes (IC50 = 0.27 µg/ml); induces production of reactive oxygen species and apoptosis and reduces cell viability of A549 cancer cells upon photoactivation with UV radiation

Formal name: 1-acetyl-2,3-dihydro-2,6,11-trihydroxy-4,8,9,13-tetramethoxy-2-methyl-1H-cyclohepta[ghi]perylene-5,12-dione, stereoisomer

Synonyms: 

Molecular weight: 546.5

CAS: 77029-83-5

Purity: ≥98%

Formulation: A solid

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