A natural ligand for the SXR (active at 0.1 to 0.5 µg/ml) and inhibitor of several CYP isoforms (IC50 = 10 µg/ml for CYP2D6)

Hyperforin (dicyclohexylammonium salt) – 500 µg

Brand:
Cayman
CAS:
238074-03-8
Storage:
-20
UN-No:
De Minimis - 1759 / 8

Hyperforin is a natural activator of the steroid X receptor (active at 0.1 to 0.5 µg/ml) and inhibitor of several cytochrome P450 (CYP) isoforms (IC50 = 10 µg/ml for CYP2D6).{9583,9584} It can also inhibit microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50 = 1 µM), 5-lipoxygenase activating protein, and sirtuins.{30723,19457,16291}  

 

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Description

A natural ligand for the SXR (active at 0.1 to 0.5 µg/ml) and inhibitor of several CYP isoforms (IC50 = 10 µg/ml for CYP2D6)

Formal name: (1R,5S,6R,7S)-4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-bicyclo[3.3.1]non-3-ene-2,9-dione, N-cyclohexylcyclohexanamine (1:1)

Synonyms:  Hyp-DCHA|Hyperforin-DCHA

Molecular weight: 718.1

CAS: 238074-03-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Product Type|Biochemicals|Small Molecule Inhibitors|Prostaglandin Synthases||Research Area|Toxicology|Drug Metabolism|Xenobiotic Sensing

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