A diterpene alkaloid with diverse biological activities; inhibits nerve stimulation-evoked contractions in isolated mouse phrenic nerve-diaphragm muscle preparations (IC50 = 118 nM); prevents carrageenan-induced paw edema in mice at 0.025 mg/kg; reduces acetic acid-induced writhing in mice (ED50 = 0.1 mg/kg); toxic to mice (LD50 = 1.9 mg/kg

Hypaconitine – 25 mg

Brand:
Cayman
CAS:
6900-87-4
Storage:
-20
UN-No:
De Minimis - 1544 / 6.1

Hypaconitine is a diterpene alkaloid that has been found in Aconitum and has diverse biological activities.{46694,46695} It inhibits nerve stimulation-evoked contractions in isolated mouse phrenic nerve-diaphragm muscle preparations (IC50 = 118 nM).{46694} Hypaconitine (0.025 mg/kg) prevents carrageenan-induced paw edema and reduces acetic acid-induced writhing in mice (ED50 = 0.1 mg/kg).{46695,46696} Hypaconitine is toxic to mice (LD50 = 1.9 mg/kg, s.c.).{46696}  

 

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Description

A diterpene alkaloid with diverse biological activities; inhibits nerve stimulation-evoked contractions in isolated mouse phrenic nerve-diaphragm muscle preparations (IC50 = 118 nM); prevents carrageenan-induced paw edema in mice at 0.025 mg/kg; reduces acetic acid-induced writhing in mice (ED50 = 0.1 mg/kg); toxic to mice (LD50 = 1.9 mg/kg, s.c.)

Formal name: (1α,6α,14α,15α,16β)-1,6,16-trimethoxy-4-(methoxymethyl)-20-methyl-aconitane-8,13,14,15-tetrol, 8-acetate 14-benzoate

Synonyms: 

Molecular weight: 615.7

CAS: 6900-87-4

Purity: ≥95%

Formulation: A solid

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