A histamine H1 receptor antagonist (Ki = 1.9 nM); binds competitively with the H1 receptor inverse agonist mepyramine in polymorphonuclear leukocytes (IC50 = 80 µM); metabolized to cetirizine in vivo; prevents histamine-induced recruitment of rolling leukocytes in rat mesentery post-capillary venules in situ (10 µM); decreases anxiety-like behavior in mice in the elevated plus maze and light-dark exploration test

Hydroxyzine – 500 mg

Brand:
Cayman
CAS:
68-88-2
Storage:
-20
UN-No:
Non-Hazardous - 1170 / 3

Hydroxyzine is a histamine H1 receptor antagonist (Ki = 1.9 nM).{39568} It binds competitively with the H1 receptor inverse agonist mepyramine (Item No. 20978) with an IC50 value of 80 µM in polymorphonuclear leukocytes.{39569} In vivo, it is metabolized to the H1 receptor antagonist cetirizine (Item No. 19686).{40229} In situ, hydroxyzine (10 µM) prevents recruitment of rolling leukocytes induced by histamine in rat mesentery post-capillary venules.{39570} Hydroxyzine also decreases anxiety-like behavior in mice, increasing the time spent in the open arms of the elevated plus maze and in the light side of the light-dark exploration test.{39571} Formulations containing hydroxyzine have been used in the treatment of anxiety and as antihistamines in the treatment of allergic rhinitis.  

 

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SKU: 24039 - 500 mg Category:

Description

A histamine H1 receptor antagonist (Ki = 1.9 nM); binds competitively with the H1 receptor inverse agonist mepyramine in polymorphonuclear leukocytes (IC50 = 80 µM); metabolized to cetirizine in vivo; prevents histamine-induced recruitment of rolling leukocytes in rat mesentery post-capillary venules in situ (10 µM); decreases anxiety-like behavior in mice in the elevated plus maze and light-dark exploration test

Formal name: 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-ethanol

Synonyms:  NSC 169188|U.C.B 4492

Molecular weight: 374.9

CAS: 68-88-2

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety

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