A pigment; inhibits LPS-induced increases in NF-κB levels and production of NO

Hydroxysafflor Yellow A – 10 mg

Brand:
Cayman
CAS:
78281-02-4
Storage:
-20
UN-No:
Non-Hazardous - /

Hydroxysafflor yellow A is a pigment that has been found in C. tinctorius and has diverse biological activities.{52728,52729,52730,52731} It inhibits LPS-induced increases in NF-κB levels and production of nitric oxide (NO), IL-1β, and TNF-α in primary mouse embryonic mesencephalic cultures when used at concentrations of 40 and 160 µM.{52729} Hydroxysafflor yellow A (1 and 3 mg/kg) decreases mean arterial pressure (MAP) and heart rate in anesthetized normotensive or spontaneously hypertensive rats.{52730} It reduces infarct volume and serum superoxide dismutase (SOD) activity in a rat model of focal transient cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 2, 4, and 8 mg/kg.{52731}  

 

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SKU: 31204 - 10 mg Category:

Description

A pigment; inhibits LPS-induced increases in NF-κB levels and production of NO, IL-1β, and TNF-α in primary mouse embryonic mesencephalic cultures at 40 and 160 µM; decreases MAP and heart rate in anesthetized normotensive or spontaneously hypertensive rats; reduces infarct volume and serum SOD activity in a rat model of focal transient cerebral ischemia induced by MCAO at 2, 4, and 8 mg/kg

Formal name: 2,4-di-β-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]-2,5-cyclohexadien-1-one

Synonyms:  Safflomin A

Molecular weight: 612.5

CAS: 78281-02-4

Purity: ≥95%

Formulation: A crystalline solid

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