A metabolite of itraconazole; exhibits in vitro antifungal activity (MIC = 0.019

Hydroxy Itraconazole – 500 µg

Brand:
Cayman
CAS:
112559-91-8
Storage:
2-8
UN-No:
Non-Hazardous - /

Hydroxy itraconazole (OH-ITZ) is an active metabolite of the antifungal agent itraconazole (Item No. 13288). Itraconazole is metabolized by the cytochrome P450 isoform 3A4 (CYP3A4) to form hydroxy itraconazole. Hydroxy itraconazole exhibits in vitro antifungal activity (MIC = 0.019, 0.078, and 0.078 mg/ml against C. albicans, A. fumigatus, and C. neoformans, respectively).{35028} Plasma concentration of hydroxy itraconazole is directly correlated to that of the parent compound and is used as an indicator of prophylaxis for fungal infections.{35029}  

 

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Description

A metabolite of itraconazole; exhibits in vitro antifungal activity (MIC = 0.019, 0.078, 0.078 mg/ml against C. albicans, A. fumigatus, and C. neoformanss, respectively); plasma concentration is used as an indicator of prophylaxis for fungal infections,

Formal name: 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-3H-1,2,4-triazol-3-one

Synonyms:  hydroxy-ITZ|OH-ITZ

Molecular weight: 721.6

CAS: 112559-91-8

Purity: ≥95% (mixture of diastereomers)

Formulation: A solid

Product Type|Biochemicals|Antifungals|Triazoles||Product Type|Biochemicals|Small Molecule Activators||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Aspergillosis||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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