An alkaloid and antiarrhythmic agent; derivative of quinidine; decreases heart rate variability; increases sinus cycle length and prolongs QRS duration and ventricular repolarization in anesthetized dogs; used as a pseudo-template in a molecular imprinting study

Hydroquinidine – 5 g

Brand:
Cayman
CAS:
1435-55-8
Storage:
-20
UN-No:
Non-Hazardous - /

Hydroquinidine is an alkaloid and derivative of the antiarrhythmic agent quinidine that decreases heart rate variability.{39149,39148,39151} It increases the length of the sinus cycle and prolongs QRS duration and ventricular repolarization in anesthetized dogs.{39148} It has also been imprinted on microspheres as a pseudo-template molecule for recognition of cinchona alkaloids.{39151} Formulations containing hydroquinidine have been studied for use in treatment of Brugada syndrome, which is a genetic disorder characterized by ventricular fibrillation and a risk of sudden death.{39150}  

 

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Description

An alkaloid and antiarrhythmic agent; derivative of quinidine; decreases heart rate variability; increases sinus cycle length and prolongs QRS duration and ventricular repolarization in anesthetized dogs; used as a pseudo-template in a molecular imprinting study,

Formal name: 10,11-dihydro-6′-methoxy-cinchonan-9S-ol

Synonyms:  (+)-Hydroquinidine|Dihydroquinidine

Molecular weight: 326.4

CAS: 1435-55-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cardiovascular System|Heart|Arrhythmia

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