An internal standard for the quantification of hydrocortisone/cortisol by GC- or LC-MS

Hydrocortisone-d4 – 500 µg

Brand:
Cayman
CAS:
73565-87-4
Storage:
-20
UN-No:
Non-Hazardous - /

Hydrocortisone-d4 is intended for use as an internal standard for the quantification of hydrocortisone/cortisol (Item No. 20739) by GC- or LC-MS. Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH).{11860,47112} It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR), with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response.{47112} Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson’s disease.{11854,11861,47113}  

 

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Description

An internal standard for the quantification of hydrocortisone/cortisol by GC- or LC-MS

Formal name: (11β)-11,17,21-trihydroxy-pregn-4-ene-3,20-dione-9,11,12,12-d4

Synonyms:  Cortisol-d4

Molecular weight: 366.5

CAS: 73565-87-4

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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