A water-soluble form of the endogenous hormone cortisol that can bind to glucocorticoid receptors

Hydrocortisone 21-hemisuccinate (sodium salt) – 1 g

Brand:
Cayman
CAS:
125-04-2
Storage:
-20
UN-No:
Non-Hazardous - /

Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol. It can bind to glucocorticoid receptors, initiating the transcription of anti-inflammatory and immunosuppressive mediators and inhibiting proinflammatory cytokine activity (IC50 = 6.7 µM for IL-6).{29361} It is commonly used to supplement media for long-term epithelial or endothelial cell cultures and to differentiate pluripotent stem cells.{29362}  

 

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Description

A water-soluble form of the endogenous hormone cortisol that can bind to glucocorticoid receptors, initiating the transcription of anti-inflammatory and immunosuppressive mediators and inhibiting proinflammatory cytokine activity (IC50 = 6.7 µM for IL-6); commonly used to supplement media for long-term epithelial or endothelial cell cultures and to differentiate pluripotent stem cells

Formal name: 21-(3-carboxy-1-oxopropoxy)-11β,17-dihydroxy-pregn-4-ene-3,20-dione, monosodium salt

Synonyms:  Cortisol 21-hemisuccinate|Hydrocortisone sodium succinate|ST51037292|U-4905

Molecular weight: 484.5

CAS: 125-04-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cell Biology|Stem Cell Research|Differentiation||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation|Immunosuppressants

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