A glucocorticoid; an agonist at the MR and glucocorticoid receptor

Hydrocortisone – 1 g

Brand:
Cayman
CAS:
50-23-7
Storage:
22
UN-No:
Non-Hazardous - /

Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH).{11860,47112} It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor, with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response.{47112} Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson’s disease.{11854,11861,47113}  

 

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Description

A glucocorticoid; an agonist at the MR and glucocorticoid receptor, with an approximately 6- to 10-fold greater affinity for MR; levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson’s disease

Formal name: (11β)-11,17,21-trihydroxy-pregn-4-ene-3,20-dione

Synonyms:  Cortisol|Dihydrocostisone|NSC 10483

Molecular weight: 362.5

CAS: 50-23-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation|Immunosuppressants

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