An orally bioavailable vasodilator and antihypertensive agent; decreases DNA methylation in Jurkat cells at a concentration of 10 μM and inhibits extracellular and intracellular ROS production in PMA-activated rat macrophages at a concentration of 100 μM; (100 μM) also decreases nitric oxide production and mRNA expression of iNOS in LPS and IFN-γ-activated rat macrophages; reduces contraction of rat aortic arterial strips induced by potassium and norepinephrine (IC50s = 2.2 and 3.06 mM

Hydralazine (hydrochloride) – 10 g

Brand:
Cayman
CAS:
304-20-1
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

Hydralazine is an orally bioavailable vasodilator and antihypertensive agent.{40710} It decreases DNA methylation in Jurkat cells at a concentration of 10 μM and inhibits extracellular and intracellular production of reactive oxygen species (ROS) in rat macrophages activated by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) at a concentration of 100 μM.{40711,40712} Hydralazine (100 μM) also decreases nitric oxide production and mRNA expression of inducible nitric oxide synthase (iNOS) in rat macrophages activated by LPS (Item Nos. 19660| 19661| 19662) and interferon-γ (IFN-γ).{40712} It reduces contraction of rat aortic arterial strips induced by potassium and norepinephrine (Item No. 16673; IC50s = 2.2 and 3.06 mM, respectively).{40713} Hydralazine (2.6 mg/kg) lowers mean arterial blood pressure (MAP) by 41.76% in conscious rats.{40714} Formulations containing hydralazine have been used in the treatment of high blood pressure and heart failure.  

 

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SKU: 23121 - 10 g Category:

Description

An orally bioavailable vasodilator and antihypertensive agent; decreases DNA methylation in Jurkat cells at a concentration of 10 μM and inhibits extracellular and intracellular ROS production in PMA-activated rat macrophages at a concentration of 100 μM; (100 μM) also decreases nitric oxide production and mRNA expression of iNOS in LPS and IFN-γ-activated rat macrophages; reduces contraction of rat aortic arterial strips induced by potassium and norepinephrine (IC50s = 2.2 and 3.06 mM, respectively); lowers MAP by 41.76% in conscious rats (2.6 mg/kg)

Formal name: 1-hydrazinyl-phthalazine, monohydrochloride

Synonyms:  1-Hydrazinophthalazine

Molecular weight: 196.6

CAS: 304-20-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Epigenetics, Transcription, & Translation|Writers|DNA/RNA Methylation||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen|iNOS||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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