An RXR antagonist (IC50 = 18 nM); reduces triglyceride content in white adipose tissue

HX 531 – 1 mg

Brand:
Cayman
CAS:
188844-34-0
Storage:
-20
UN-No:
Non-Hazardous - /

HX 531 is an antagonist of the retinoid X receptor (RXR) with an IC50 value of 18 nM that inhibits 9-cis retinoic acid (Item No. 14587)-induced transactivation of RXR.{32938} It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet.{32939}  

 

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SKU: 20762 - Category:

Description

An RXR antagonist (IC50 = 18 nM); reduces triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet

Formal name: 4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)-benzoic acid

Synonyms: 

Molecular weight: 483.6

CAS: 188844-34-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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