Description
A histamine H1 receptor agonist; binds to the histamine H4 receptor (Ki = 1.2 µM) but does not increase calcium mobilization in HEK293 cells expressing the receptor at 10 µM; increases intracellular calcium and inositol phosphate levels (EC50s = 19 and 30 µM, respectively) in human peripheral blood lymphocytes; increases proliferation of immortalized mouse small, but not large, cholangiocytes, at 10 µM; increases levels of sheep red blood cell-induced IgG and IgM antibodies in rabbit serum at 10 µg/kg twice per day; induces scratching in mice at an intradermal dose of 0.2 µmol, an effect that is reduced by the H1 receptor antagonist terfenadine
Formal name: 6-[[2-(1H-imidazol-5-yl)ethyl]amino]-N-[4-(trifluoromethyl)phenyl]-heptanamide, 2Z-butenedioate
Synonyms: Histamine trifluromethyl toluidine
Molecular weight: 614.6
CAS: 195867-54-0
Purity: ≥98%
Formulation: A solid
