A mycotoxin and an active metabolite of T-2 toxin; reduces viability of a variety of cancer cells (IC50s = 3.1-23 ng/ml) and HUVECs (IC50 = 56.4 ng/ml); induces oxidative stress

HT-2 Toxin – 1 mg

Brand:
Cayman
CAS:
26934-87-2
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin (Item No. 11444).{53282,31995} Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.{31995} HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50 values ranging from 3.1 to 23 ng/ml and human umbilical vein endothelial cells (HUVECs) with an IC50 value of 56.4 ng/ml.{53282} It induces oxidative stress, DNA damage, and autophagy in, as well as halts the development of, cultured mouse embryos when used at a concentration of 10 nM.{59456} HT-2 toxin has been found in cereal grains and food products.{59457,59458}  

 

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Description

A mycotoxin and an active metabolite of T-2 toxin; reduces viability of a variety of cancer cells (IC50s = 3.1-23 ng/ml) and HUVECs (IC50 = 56.4 ng/ml); induces oxidative stress, DNA damage, and autophagy in, as well as halts the development of, cultured mouse embryos at 10 nM

Formal name: 12,13-epoxy-trichothec-9-ene-3α,4β,8α,15-tetrol, 15-acetate 8-(3-methylbutanoate)

Synonyms:  NSC 278571

Molecular weight: 424.5

CAS: 26934-87-2

Purity: ≥99%

Formulation: A powder

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione||Research Area|Plant Biology||Research Area|Toxicology|Cell Health & Viability||Research Area|Toxicology|Environmental|Agriculture

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