Immunogen: Full-length human recombinant Hsp27 protein • Host: Mouse • Species Reactivity: (+) Human • Cross Reactivity: (-) Hsp60 • Applications: ELISA

Hsp27 (HspB1) Monoclonal Antibody (Clone 6A5) – 100 µg

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Cayman
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Heat shock protein 27 (Hsp27), also known as heat shock protein beta-1 (HspB1), is a member of the small heat shock protein (sHSP) family that is upregulated during conditions of cellular stress including heat shock, radiation, hypoxia, and exposure to reactive oxygen species (ROS).{40293,40294} It is composed of an N-terminal domain, a highly conserved alpha-crystallin domain, and a C-terminal domain. Hsp27 functions as a molecular chaperone to prevent protein aggregation in an ATPase-independent manner. This chaperone activity is altered by changes in oligomerization state or by post-translational modifications including phosphorylation at serine residues 15 and 82, which increases affinity for damaged polypeptides in response to heat shock.{40754} Hsp27 also works in complex with other chaperone proteins, such as Hsp70 (Item Nos. 22739 | 23002), to correct misfolded proteins. This protein also plays a role in apoptosis, proteasome activation, cell differentiation, and has been shown to interact with actin and intermediate filaments.{40295,40296,40297} Mutations in HSPB1 have been linked to hereditary neuromuscular diseases and cause Charcot-Marie-Tooth Disease Type 2 (CMT-2).{40298} Cayman’s Hsp27 (HspB1) Monoclonal Antibody can be used for Western blot and ELISA applications. The antibody recognizes Hsp27 (HspB1) at 25 kDa from human samples.  

 

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SKU: 25692 - 100 µg Category:

Description

Immunogen: Full-length human recombinant Hsp27 protein • Host: Mouse • Species Reactivity: (+) Human • Cross Reactivity: (-) Hsp60 • Applications: ELISA, IF, IHC, and WB

Synonyms: Estrogen-Regulated 24 kDa Protein|Heat Shock Protein 27|Heat Shock Protein Beta-1|Stress-Responsive Protein 27

Immunogen: Full-length human recombinant Hsp27 protein

Formulation: 100 µg of protein G-purified monoclonal antibody

Isotype: IgG1

Applications: ELISA, IF, IHC, and WB

Origin:

Stability: 365 days

Application|ELISA||Application|Immunofluorescence||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cellular Chaperones||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System||Research Area|Neuroscience|Neurodegenerative Disorders

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