A PI3Kα inhibitor (IC50 = 0.8 nM) that demonstrates antiproliferative activity in T47D

HS-173 – 5 mg

Brand:
Cayman
CAS:
1276110-06-5
Storage:
-20
UN-No:
Non-Hazardous - /

HS-173 is an imidazopyridine analog that acts as a PI3Kα inhibitor with an IC50 value of 0.8 nM.{31012} It demonstrates antiproliferative activity in T47D, SK-BR-3, and MCF-7 cells with IC50 values of 0.6, 1.5, and 7.8 μM, respectively.{31012} HS-173 is reported to induce apoptosis by arresting the cell cycle at the G2/M phase and by activating caspases.{31013,31014} It has also been shown to block VEGF-induced angiogenesis both in vitro and in vivo.{31013}  

 

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Description

A PI3Kα inhibitor (IC50 = 0.8 nM) that demonstrates antiproliferative activity in T47D, SK-BR-3, and MCF-7 cells with IC50 values of 0.6, 1.5, and 7.8 μM, respectively; induces apoptosis and blocks angiogenesis both in vitro and in vivo

Formal name: 6-[5-[(phenylsulfonyl)amino]-3-pyridinyl]-imidazo[1,2-a]pyridine-3-carboxylic acid, ethyl ester

Synonyms: 

Molecular weight: 422.5

CAS: 1276110-06-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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