Description
A ceramide analog and inhibitor of CERT; inhibits binding of a ceramide probe to the isolated START domain of CERT (EC50 = 4 μM in a TR-FRET assay); inhibits conversion of the fluorescent ceramide analog C5-DMB-Cer to C5-DMB-sphingomyelin in CHO and HeLa cells at 2.5 μM; inhibits sphingomyelin synthesis in wild-type, but not ATP-dependent ceramide transport-deficient, CHO cells at 1 μM
Formal name: N-[(1R,3S)-3-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]-dodecanamide
Synonyms: (1R,3S)-HPA-12
Molecular weight: 363.5
CAS: 383418-30-2
Purity: ≥98%
Formulation: A solid