A naturally occurring alkaloid found in a variety of plants

Hordenine – 1 mg

Brand:
Cayman
CAS:
539-15-1
Storage:
-20
UN-No:
Non-Hazardous - /

Hordenine (Item No. 21626) is a naturally occurring alkaloid found in a variety of plants, most commonly germinated barley (Hordeum species) from which the name is derived, and is structurally classified as a phenethylamine.{33813,33816} It is biosynthesized by the step-wise double methylation of tyramine (Item No. 18601).{33815} Hordenine binds to and activates the dopamine D2 receptor (Ki = 13 µM) but antagonizes D2 receptor β-arrestin recruitment.{33814} It inhibits tyrosinase activity and expression at concentrations ≥ 50 µM resulting in reduced melanin accumulation in human melanocytes.{33816} Hordenine is present in significant amounts in beer and can be measured in serum in the free form, for up to 2 hours, and the glucuronidated form, for up to 6 hours, after beer consumption.{33817} This product is intended for research and forensic applications.  

 

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Description

A naturally occurring alkaloid found in a variety of plants, most commonly germinated barley; binds to and activates the dopamine D2 receptor (Ki = 13 µM); blocks melanin accumulation in human melanocytes; can be measured in serum following beer consumption

Formal name: 4-[2-(dimethylamino)ethyl]-phenol

Synonyms:  N,N-dimethyl Tyramine|N,N-dimethyl-4-Hydroxyphenylethylamine

Molecular weight: 165.2

CAS: 539-15-1

Purity: ≥95%

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Forensic Chemistry & Toxicology|Hallucinogens|Phenethylamines||Research Area|Forensic Chemistry & Toxicology|Stimulants|Phenethylamines

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