A dopamine metabolite; formed via deamination of dopamine by MAO to produce DOPAC followed by DOPAC metabolism by COMT; undergoes hydrogen peroxide-dependent oxidation in the presence of horseradish peroxidase to form a fluorescent dimer with ex/em = 312/420 nm

Homovanillic Acid – 250 mg

Brand:
Cayman
CAS:
306-08-1
Storage:
-20
UN-No:
Non-Hazardous - /

Homovanillic acid (HVA) is a dopamine metabolite.{36669} It is formed via deamination of dopamine by monoamine oxidase (MAO) to produce 3,4-dihydroxyphenylacetic acid (DOPAC; Item No. 24912) followed by DOPAC metabolism by catechol-O-methyltransferase (COMT). HVA undergoes hydrogen peroxide-dependent oxidation in the presence of horseradish peroxidase to form a fluorescent dimer that displays excitation/emission maxima of 312/420 nm, respectively.{43942} It has been used to quantify hydrogen peroxide production in macrophages and neutrophils.  

 

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SKU: 27307 - 250 mg Category:

Description

A dopamine metabolite; formed via deamination of dopamine by MAO to produce DOPAC followed by DOPAC metabolism by COMT; undergoes hydrogen peroxide-dependent oxidation in the presence of horseradish peroxidase to form a fluorescent dimer with ex/em = 312/420 nm, respectively; has been used to quantify hydrogen peroxide production in macrophages and neutrophils

Formal name: 4-hydroxy-3-methoxy-benzeneacetic acid

Synonyms:  HVA|NSC 16682|Vanilacetic Acid

Molecular weight: 182.2

CAS: 306-08-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Immunology & Inflammation||Research Area|Neuroscience||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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