A flavonoid glycoside; scavenges DPPH radicals (IC50 = 0.35 µg/ml); reverses hydrogen peroxide-induced decreases in GSH levels and GPX and SOD activity in HL-7702 cells from 1-100 µg/ml; prevents palmitic acid-induced increases in protein levels of TLR4

Homoplantaginin – 50 mg

Brand:
Cayman
CAS:
17680-84-1
Storage:
-20
UN-No:
Non-Hazardous - /

Homoplantaginin is a flavonoid glycoside that has been found in S. plebeia and has antioxidant and anti-inflammatory activities.{46804,46805,46806} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals with an IC50 value of 0.35 µg/ml in a cell-free assay.{46805} Homoplantaginin reverses hydrogen peroxide-induced decreases in glutathione (GSH) levels and glutathione peroxidase (GPX) and superoxide dismutase (SOD) activity in HL-7702 cells when used at concentrations ranging from 1 to 100 µg/ml. It reduces protein levels of toll-like receptor 4 (TLR4), MyD88, caspase-1, and IL-1β induced by palmitic acid (Item No. 10006627) in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 1 and 10 µM.{46806} Homoplantaginin (50 and 100 mg/kg) decreases serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), TNF-α, and IL-1 levels, as well as reduces liver inflammatory cell infiltration and hepatocyte necrosis in a mouse model of immunological liver injury induced by Bacillus Calmette-Guérin (BCG) vaccine and LPS.{46805}  

 

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SKU: 29853 - 50 mg Category:

Description

A flavonoid glycoside; scavenges DPPH radicals (IC50 = 0.35 µg/ml); reverses hydrogen peroxide-induced decreases in GSH levels and GPX and SOD activity in HL-7702 cells from 1-100 µg/ml; prevents palmitic acid-induced increases in protein levels of TLR4, MyD88, caspase-1, and IL-1β levels in HUVECs at 1 and 10 µM; decreases serum ALT, AST, TNF-α and IL-1 levels, as well as reduces liver inflammatory cell infiltration and hepatocyte necrosis in a mouse model of immunological liver injury induced by BCG vaccine and LPS

Formal name: 7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one

Synonyms:  Hispidulin-7-O-D-glucoside

Molecular weight: 462.4

CAS: 17680-84-1

Purity: ≥95%

Formulation: A solid

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