Description
Heme oxygenase-2 (HO-2) is a constitutively active heme oxygenase encoded by the HMOX2 gene.{6104,40054} It is a membrane-bound enzyme that catalyzes the cleavage of heme to give carbon monoxide (CO), ferrous ions (Fe2+), and biliverdin, with biliverdin being further processed into bilirubin. HO-2 is found in neurons, testes, and endothelial and smooth muscle cells from cerebral vessels.{40054} HO-2 protects against apoptotic neuronal cell death in models of ischemic injury and oxidative stress. It also acts as an oxygen sensor to inhibit systemic vascular reactivity and reduce cell death in response to hypoxia. Cayman’s HO-2 Monoclonal Antibody (Clone 5D10) can be used for Western blot and ELISA applications. The antibody recognizes HO-2 at 36 kDa from human samples.
Synonyms: Heme Oxygenase-2|HMOX2|HO-2
Immunogen: Full length human recombinant HO-2 protein
Formulation: 500 µg protein G-purified monoclonal antibody
Isotype: IgG1
Applications: ELISA and WB
Origin:
Stability: 365 days
Application|ELISA||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cellular Chaperones||Research Area|Neuroscience
