Antigen: full-length recombinant human HMGB1 • Host: mouse

HMGB1 Monoclonal Antibody (Clone IMG19N12A1) – 1 ea

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Cayman
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High Mobility Group Protein B1 (HMGB1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE).{20300} It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.{20304}  

 

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SKU: 11514 - 1 ea Category:

Description

Antigen: full-length recombinant human HMGB1 • Host: mouse, clone IMG19N12A1 • Isotype: IgG1k • Cross Reactivity: (+) human and mouse HMGB1 • Application: WB • HMGB1 is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE).

Synonyms: High Mobility Group Protein B1|HMG1

Immunogen: full-length recombinant human HMGB1

Formulation: 100 µg in 200 µl of PBS containing 0.05% BSA and 0.05% sodium azide

Isotype: IgG2bĸ

Applications: WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock||Research Area|Infectious Disease

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