A third generation EGFR tyrosine kinase inhibitor that inhibits both EGFR activating and T790M resistance mutations

HM61713 – 1 mg

Brand:
Cayman
CAS:
1353550-13-6
Storage:
-20
UN-No:
Non-Hazardous - /

HM61713 is a third generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that inhibits both EGFR activating and T790M resistance mutations, while sparing wild-type EGFR.{32030,32031} It has been investigated in Phase II clinical trials in patients with EGFR T790M mutation-positive non-small cell lung cancer (NSCLC), who developed resistance to earlier generations of EGFR tyrosine kinase inhibitor therapy.{32031}  

 

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Description

A third generation EGFR tyrosine kinase inhibitor that inhibits both EGFR activating and T790M resistance mutations, while sparing wild-type EGFR

Formal name: N-[3-[[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide

Synonyms:  BI-1482694|Olmutinib

Molecular weight: 486.6

CAS: 1353550-13-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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