Description
A PRMT5 inhibitor; inhibits the growth of multiple AML cell lines and patient-derived tumor samples (IC50s = 7.21-21.46 and 3.98-8.72 μM, respectively); selective for PRMT5, lacking activity against PRMT1, PRMT4, and PRMT7 in an enzyme assay; induces myeloid differentiation of THP-1 cells and increases CD11b expression in a dose-dependent manner; increases expression of miR-29b mRNA resulting in a 4-fold decrease in FLT3 activity in THP-1 cells expressing an FLT3 luciferase reporter,
Formal name: 9-ethyl-N-[(2-methoxyphenyl)methyl]-9H-carbazole-3-methanamine, monohydrochloride
Synonyms:
Molecular weight: 380.9
CAS: 1158279-20-9
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation