Immunogen: Synthetic peptide from the N-terminal region of human histone H3 (dimethyl K4) conjugated to KLH • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) Histone H3 monomethylated at K4 (~100%); (+) Histone H3 trimethylated at K4 (~20%); (+) Histone H3 dimethylated at K9 (~20%) • Applications: • MW = ~16 kDa

Histone H3K4Me2 Polyclonal Antibody – 1 ea

Brand:
Cayman
Storage:

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Dimethylation of H3K4 is catalyzed by SET domain-containing histone methyltransferases, including SET1, MLL1, -2, -3, and -4, and SMYD3, and dysregulation of these methyltransferases is associated with various diseases, including breast and prostate cancer and Alzheimer’s disease in humans. H3K4Me2 is highly enriched in the promoter region of transcriptionally active genes, as well as primed, inactive genes that are targeted for future transcription.{47296} Cayman’s Histone H3K4Me2 Polyclonal Antibody can be used for ELISA and Western blot applications. It detects H3K4Me2 at ~16 kDa from human samples.  

 

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SKU: 18198 - 1 ea Category:

Description

Immunogen: Synthetic peptide from the N-terminal region of human histone H3 (dimethyl K4) conjugated to KLH • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) Histone H3 monomethylated at K4 (~100%); (+) Histone H3 trimethylated at K4 (~20%); (+) Histone H3 dimethylated at K9 (~20%) • Applications: • MW = ~16 kDa

Synonyms: Histone H3 containing dimethylated lysine 4

Immunogen: Synthetic peptide from the N-terminal region of human Histone H3 (dimethyl K4) conjugated to KLH

Formulation: 500 µl of peptide affinity-purified antibody

Isotype:

Applications: ELISA and WB

Origin:

Stability: 730 days

Application|ELISA||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Methylated||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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