Description
Histone H3 undergoes many modifications including acetylation, methylation, and phosphorylation that are important for regulation of gene transcription. Lysine 36 of histone 3 (H3K36) has functionally relevant acetylation and methylation states with roles in transcriptional activation. More than 90% of chondroblastomas contain a heterozygous mutation, replacing H3K36 with methionine 36 (H3K36M) in the histone H3 variant H3.3.{32234} This antibody reacts to the H3K36M mutant and does not detect wild-type histone H3.
Synonyms:
Immunogen: A peptide corresponding to histone H3K36M mutant
Formulation: 100 or 400 µl of protein A-affinity purified monoclonal antibody
Isotype: IgG
Applications: ELISA, IHC, WB
Origin:
Stability: 365 days
Application|ELISA||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides
