Description
Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Dimethylation of histone 3 lysine 14 (H3K14Me2) is enriched in the promoter region of tumor suppressor candidate 3 (TUSC3), but not that of GAPDH, in DLD-1 and HCT116 cells.{58054} Ubiquitin-like PHD and RING finger domain-containing protein 1 (UHRF1) can bind to dimethylated H3K14 and suppress acetylation of H3K14. H3K14Me2 levels increase during transdifferentiation of rat Thy-1(+) Lin(-) bone marrow cells into hepatocytes in vitro.{58055} Cayman’s Histone H3K14Me2 Monoclonal Antibody can be used for ELISA, multiplex-based assay, and Western blot (WB) applications.
Synonyms: Dimethylated Histone H3 Lysine 14
Immunogen: Peptide corresponding to H3K14Me2
Formulation: 100 µg of protein A affinity-purified monoclonal antibody
Isotype: IgG
Applications: ELISA, multiplex-based assays, and WB
Origin:
Stability: 365 days
Application|ELISA||Application|Multiplex||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cell Biology|Stem Cell Research|Differentiation||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Methylated||Research Area|Epigenetics, Transcription, & Translation|Readers|PHD Domains||Research Area|Epigenetics, Transcription, & Translation|Readers|Tandem Tudor & Tudor-like Domains||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation||Research Area|Epigenetics, Transcription, & Translation|Writers|Ubiquitination
