Description
Histone H3 is a nuclear protein and a component of the nucleosome core that is essential for organizing genomic DNA in eukaryotic nuclei.{56209} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications, including citrullination. Histone H3 is subject to citrullination of arginine residues by peptidyl arginine deiminase 4 (PAD4) at positions 2, 8, 17 and 26, and this citrullination blocks methylation of these residues by protein-arginine methyltransferase 4 (PRMT4) and induces transcriptional repression of target genes. Citrullinated histone H3 is a component of neutrophil extracellular traps (NETs) that acts as an autoantigen to induce production of anti-citrullinated protein antibodies associated with various diseases such as sepsis, multiple sclerosis, rheumatoid arthritis, and multiple myeloma.{56209,30129,35770,46253} Cayman’s Histone H3 (Citrullinated R2 + R8 + R17) Polyclonal Antibody can be used for ELISA and Western blot applications. The antibody recognizes citrullinated histone H3 at 16 kDa from human samples.
Synonyms:
Immunogen: Histone H3 peptide with citrullinations at R2, R8, and R17
Formulation: 500 µl of peptide affinity-purified IgG
Isotype:
Applications: ELISA, WB
Origin:
Stability: 365 days
Application|ELISA||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Citrullinated||Research Area|Epigenetics, Transcription, & Translation|Writers|Citrullination||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Innate Immunity|NETosis||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock||Research Area|Neuroscience
