A flavonoid with diverse biological activities; inhibits PAF-

Hispidulin – 25 mg

Brand:
Cayman
CAS:
1447-88-7
Storage:
-20
UN-No:
Non-Hazardous - /

Hispidulin is a flavonoid originally isolated from A. montana with diverse biological activities.{45323,45324,45325,45326,45327} It inhibits platelet aggregation induced by platelet-activating factor (PAF), arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), and ADP (IC50s = 20, 4, and 13 μM, respectively).{45323} Hispidulin inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 cells and bone marrow-derived macrophages (BMMs).{45324} In vivo, hispidulin (25 μg/kg) inhibits LPS-induced bone resorption in mice. It inhibits sphingosine kinase 1 (SPHK1) and induces ceramide accumulation and apoptosis in Caki-2 renal carcinoma cells in vitro and inhibits tumor growth in a Caki-2 mouse xenograft model.{45325} Pretreatment with hispidulin (40 mg/kg) reduces cognitive deficits in the Morris water maze induced by sevoflurane (Item No. 23996) in aged rats.{45326} It also decreases infarct size and brain edema in a rat model of focal cerebral ischemia and reperfusion injury.{45327}  

 

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SKU: 26383 - 25 mg Category:

Description

A flavonoid with diverse biological activities; inhibits PAF-, arachidonic acid-, and ADP-induced platelet aggregation (IC50s = 20, 4, and 13 μM, respectively); inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 cells and BMMs; inhibits LPS-induced bone resorption in mice at 25 μg/kg; inhibits tumor growth in a Caki-2 mouse xenograft model; reduces sevoflurane-induced cognitive deficits in aged rats at 40 mg/kg; decreases infarct size and brain edema in a rat model of focal cerebral ischemia and reperfusion injury

Formal name: 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one

Synonyms:  6-Methoxyapigenin|Dinatin|NSC 122415

Molecular weight: 300.3

CAS: 1447-88-7

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|Other Lipid Kinases||Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neuroprotection|Ischemia

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