Description
A polyphenol with diverse biological activities; scavenges radicals at 14.47 equivalents of trolox in a TEAC assay; inhibits transcriptional activity of NF-κB, decreases iNOS expression, and decreases generation of ROS in LPS-induced macrophage RAW 264.7 cells; inhibits apoptosis and increases insulin secretion in hydrogen peroxide-treated RINm5F pancreatic β-cells.; inhibits PKCβ (IC50 = 2 μM); inhibits BACE1 (IC50 = 4.9 μM) and PE (IC50 = 16 μM) but not other serine proteases when used at a concentration of 40 µM (0.6, 0, 8.2, and 3.1% inhibition of chymotrypsin, trypsin, elastase, and TACE, respectively),
Formal name: 6-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-4-hydroxy-2H-pyran-2-one
Synonyms:
Molecular weight: 246.2
CAS: 555-55-5
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic
