A tropolone with diverse biological activities; has antifungal and antibacterial properties; inhibitors proliferation of HCT-116 and SW-620 colon cancer cells (IC50s = 4.5 and 4.4 µM

Hinokitiol – 100 mg

Brand:
Cayman
CAS:
499-44-5
Storage:
-20
UN-No:
Non-Hazardous - /

Hinokitiol is a tropolone originally isolated from the heart wood of T. plicata that has diverse biological activities, including antifungal, antibacterial, and antiproliferative properties.{39284,39285,39288} It inhibits proliferation of HCT-116 and SW-620 colon cancer cells (IC50s = 4.5 and 4.4 µM, respectively), arrests the cell cycle, and induces apoptosis.{39286} In mouse xenograft models of colon cancer, hinokitiol (100 mg/kg) decreases tumor volume and weight. It also has effects on platelets, inhibiting thrombus formation in mice and selectively inhibiting platelet-type 12-lipoxygenase (12-LO; IC50 = 0.1 µM) over leukocyte-type 12-LO (IC50 = 50 µM) in vitro.{39287,39289}  

 

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Description

A tropolone with diverse biological activities; has antifungal and antibacterial properties; inhibitors proliferation of HCT-116 and SW-620 colon cancer cells (IC50s = 4.5 and 4.4 µM, respectively), arrests the cell cycle, and induces apoptosis; decreases tumor volume and weight in mouse xenograft models of colon cancer at a dose of 100 mg/kg; inhibits thrombus formation in mice; inhibits platelet-type 12-LO (IC50 = 0.1 µM) ,

Formal name: 2-hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one

Synonyms:  4-isopropyl Tropolone|NSC 18804|β-Thujaplicin

Molecular weight: 164.2

CAS: 499-44-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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